After Austin joined the show as Julian though, they fell in love and remained in a relationship on-and-off for four years.
In May 2008, they officially became an item before ending it exactly a year later. The actress dated her third man from the series in the shape of Austin Nichols.
In fact, they were first linked back in 2006 when Sophia's divorce to Chad was being finalized but nothing came of it.
Or is Hakeem smashing his onscreen mama to smithereens?
Or maybe Andre and Rhonda Lyon really are together.
Find out who below: Perhaps the couple of One Tree Hill (on and off-screen), Chad Michael Murray and Sophia Bush began dating the year that the show began, getting engaged in May 2004 and marrying the following year.
Here they are at the peak of their love story on-screen: Sadly, just five months into married life, our hopes and dreams for the real-life Brooke and Lucas fell apart as their marriage crumbled following reports that Chad had cheated on his wife with Paris Hilton. Following her turbulent break-up with Chad, Sophia didn't beat around the bush and began something with co-star James Lafferty.
Soon after his marriage crumbled to tiny pieces, Chad began dating Kenzie after she appeared on the show as a cheerleader and just three months after being together, they were engaged.
This continued on for seven years, before they decided to break up.
Hit the flizzip to see which “Empire” cast members are together in real life…
“Empire” stars Andre Lyon and Anika Calhoun are family on-screen … They went to a wedding together and people who went to the reception tell us they were super affectionate at times, but still conscious people were looking. While these two have yet to speak on their rumored coupledom they’ve actually been spotted together on more than one occasion.
Now: After a slew of unparalleled "Challenge" appearances, B married Matt Ciriello and together they have two children -- six-year-old Julia and four-year-old Nicholas.