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Analytical epidemiological studies, using predominantly older drivers, have documented increased crash risks, with a relative risk of 2.3 Leveille, Buchner, Koepsell, Mc Closkey, Wolf, and Gagner (1994).Ramaekers (2003) summarized the major results of all studies published from 1983 to 2000 that investigated the effect of antidepressants on driving performance.

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Tricyclic antidepressants (TCAs) are as effective as selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression and provide an alternative treatment if an SSRI is unsuitable or not tolerated.

In general TCAs are less well tolerated than SSRIs, mainly due to anticholinergic effects, and are more toxic in overdose.

In other words, never stop taking the medication because you feel better and think you don't need it. (The biggest problem with this medicine is that people stop taking it as soon as they feel better.

Then their symptoms come back.) Call weekdays (818) 790-4300, for more information.

It should be noted that although Ramaekers (2003) categorized paroxetine and nefazodone as nonsedating, in practice they are considered to be sedating.

While reading this article, if you are taking these medications for an indication besides depression, just substitute your particular problem for talk about "depression," since the medication otherwise works the same way. They are a unique family of medications completely different from Valium, sedatives, narcotics, etc. Some may cause drowsiness, but this is usually temporary. Some people develop a minor tremor (shaking) of the hands.Examples of nonsedating antidepressants include the monoamine oxidase inhibitor moclobemide, the selective serotonin reuptake inhibitors fluoxetine, paroxetine, and nefazodone, and the serotonin and norepinephrine uptake inhibitor (SNRI) venlafaxine.The effect of antidepressants on driving behavior was assessed with the standard deviation of lateral position (SDLP) test.Recently we have discussed the place of TCAs in the treatment of depression in the elderly.In the treatment of depression, SSRIs are more commonly used, than TCAs as first-line agents in most situations.TCAs may also cause problematic adverse effects especially in the elderly.